Strength in Parkinson's disease: Relationshp to rate of force generation and clinical status
Identifieur interne : 002138 ( Main/Exploration ); précédent : 002137; suivant : 002139Strength in Parkinson's disease: Relationshp to rate of force generation and clinical status
Auteurs : Corcos [États-Unis, Royaume-Uni] ; Chiung-Mei Chen [Taïwan, Royaume-Uni] ; Niall P. Quinn [Royaume-Uni] ; John Mcauley [Royaume-Uni] ; John C. Rothwell [Royaume-Uni]Source :
- Annals of Neurology [ 0364-5134 ] ; 1996-01.
Abstract
Maximum elbow flexor and extensor muscle strength was measured in 9 patients with Parkinson's disease on and off antiparkinsonian medication. In addition, the rate of force generation, the rate of actively returning force to resting levels, and passive release of force “relaxation” were measured in submaximal contractions. The measures of strength and contraction time were correlated with changes in clinical status as measured by the Unified Parkinson's Disease Rating Scale. When patients were off medication, their reduction in strength was significantly greater in extension than flexion. The reduction in flexion strength did not reach statistical significance. The extensor weakness was primarily due to decreased tonic activation of the extensor muscles and not to muscle coactivation. Muscle relaxation time was much more prolonged than was force generation time or active force return time. The increase in relaxation time and the decrease in extensor strength both correlated with changes in clinical status. Finally, changes in extensor torque correlated with the time to actively return force, suggesting that reduced strength is related to a reduced ability to generate rapid contractions in some patients with Parkinson's disease. These results suggest that there is an asymmetric distribution of muscle weakness in Parkinson's disease and that selected measures of muscle strength and muscle relaxation correlate with changes in clinical status.
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DOI: 10.1002/ana.410390112
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Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Movement and Balance Unit, The National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-01">1996-01</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="79">79</biblScope><biblScope unit="page" to="88">88</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">954A25EB25D4361DF994EF63387471FF91D702AB</idno><idno type="DOI">10.1002/ana.410390112</idno><idno type="ArticleID">ANA410390112</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Maximum elbow flexor and extensor muscle strength was measured in 9 patients with Parkinson's disease on and off antiparkinsonian medication. In addition, the rate of force generation, the rate of actively returning force to resting levels, and passive release of force “relaxation” were measured in submaximal contractions. The measures of strength and contraction time were correlated with changes in clinical status as measured by the Unified Parkinson's Disease Rating Scale. When patients were off medication, their reduction in strength was significantly greater in extension than flexion. The reduction in flexion strength did not reach statistical significance. The extensor weakness was primarily due to decreased tonic activation of the extensor muscles and not to muscle coactivation. Muscle relaxation time was much more prolonged than was force generation time or active force return time. The increase in relaxation time and the decrease in extensor strength both correlated with changes in clinical status. Finally, changes in extensor torque correlated with the time to actively return force, suggesting that reduced strength is related to a reduced ability to generate rapid contractions in some patients with Parkinson's disease. These results suggest that there is an asymmetric distribution of muscle weakness in Parkinson's disease and that selected measures of muscle strength and muscle relaxation correlate with changes in clinical status.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Illinois</li></region><settlement><li>Londres</li></settlement></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Corcos" sort="Corcos" uniqKey="Corcos" last="Corcos">Corcos</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Corcos" sort="Corcos" uniqKey="Corcos" last="Corcos">Corcos</name></region><name sortKey="Chen, Chiung Ei" sort="Chen, Chiung Ei" uniqKey="Chen C" first="Chiung-Mei" last="Chen">Chiung-Mei Chen</name><name sortKey="Chen, Chiung Ei" sort="Chen, Chiung Ei" uniqKey="Chen C" first="Chiung-Mei" last="Chen">Chiung-Mei Chen</name><name sortKey="Mcauley, John" sort="Mcauley, John" uniqKey="Mcauley J" first="John" last="Mcauley">John Mcauley</name><name sortKey="Mcauley, John" sort="Mcauley, John" uniqKey="Mcauley J" first="John" last="Mcauley">John Mcauley</name><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name></country><country name="Taïwan"><noRegion><name sortKey="Chen, Chiung Ei" sort="Chen, Chiung Ei" uniqKey="Chen C" first="Chiung-Mei" last="Chen">Chiung-Mei Chen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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